Wang, JuanLin, XueqiuWang, SuWang, ChenfeiWang, QixuanDuan, XikunLu, PengWang, QianWang, ChengyangLiu, X. ShirleyHuang, Jinyan2014-07-072014Wang, J., X. Lin, S. Wang, C. Wang, Q. Wang, X. Duan, P. Lu, et al. 2014. “PHF8 and REST/NRSF co-occupy gene promoters to regulate proximal gene expression.” Scientific Reports 4 (1): 5008. doi:10.1038/srep05008. http://dx.doi.org/10.1038/srep05008.2045-2322http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406884Chromatin regulators play an important role in the development of human diseases. In this study, we focused on Plant Homeo Domain Finger protein 8 (PHF8), a chromatin regulator that has attracted special concern recently. PHF8 is a histone lysine demethylase ubiquitously expressed in nuclei. Mutations of PHF8 are associated with X-linked mental retardation. It usually functions as a transcriptional co-activator by associating with H3K4me3 and RNA polymerase II. We found that PHF8 may associate with another regulator, REST/NRSF, predominately at promoter regions via studying several published PHF8 chromatin immunoprecipitation-sequencing (ChIP-Seq) datasets. Our analysis suggested that PHF8 not only activates but may also repress gene expression.en-USJournal Article2014-07-0710.1038/srep05008