Beecham, Ashley HPatsopoulos, NikolaosXifara, Dionysia KDavis, Mary FKemppinen, AnuCotsapas, ChrisShahi, Tejas SSpencer, ChrisBooth, DavidGoris, AnOturai, AnnetteSaarela, JannaFontaine, BertrandHemmer, BernhardMartin, ClaesZipp, FraukeD’alfonso, SandraMartinelli-Boneschi, FilippoTaylor, BruceHarbo, Hanne FKockum, IngridHillert, JanOlsson, TomasBan, MariaOksenberg, Jorge RHintzen, RogierBarcellos, Lisa FAgliardi, CristinaAlfredsson, LarsAlizadeh, MehdiAnderson, CarlAndrews, RobertSøndergaard, Helle BachBaker, AmieBand, GavinBaranzini, Sergio EBarizzone, NadiaBarrett, JeffreyBellenguez, CélineBergamaschi, LauraBernardinelli, LuisaBerthele, AchimBiberacher, ViolaBinder, Thomas M CBlackburn, HannahBomfim, Izaura LBrambilla, PaolaBroadley, SimonBrochet, BrunoBrundin, LouBuck, DorotheaButzkueven, HelmutCaillier, Stacy JCamu, WilliamCarpentier, WassilaCavalla, PaolaCelius, Elisabeth GComan, IrèneComi, GiancarloCorrado, LuciaCosemans, LeentjeCournu-Rebeix, IsabelleCree, Bruce A CCusi, DanieleDamotte, VincentDefer, GillesDelgado, Silvia RDeloukas, Panosdi Sapio, AlessiaDilthey, Alexander TDonnelly, PeterDubois, BénédicteDuddy, MartinEdkins, SarahElovaara, IrinaEsposito, FedericaEvangelou, NikosFiddes, BarnabyField, JudithFranke, AndreFreeman, ColinFrohlich, Irene YGalimberti, DanielaGieger, ChristianGourraud, Pierre-AntoineGraetz, ChristianeGraham, AndrewGrummel, VerenaGuaschino, ClaraHadjixenofontos, AthenaHakonarson, HakonHalfpenny, ChristopherHall, GillianHall, PerHamsten, AndersHarley, JamesHarrower, TimothyHawkins, CliveHellenthal, GarrettHillier, CharlesHobart, JeremyHoshi, MuniHunt, Sarah EJagodic, MajaJelčić, IlijasJochim, AngelaKendall, BrianKermode, AllanKilpatrick, TrevorKoivisto, KeijoKonidari, IoannaKorn, ThomasKronsbein, HelenaLangford, CordeliaLarsson, MalinLathrop, MarkLebrun-Frenay, ChristineLechner-Scott, JeannetteLee, Michelle HLeone, Maurizio ALeppä, VirpiLiberatore, GiuseppeLie, Benedicte ALill, Christina MLindén, MagdalenaLink, JennyLuessi, FelixLycke, JanMacciardi, FabioMännistö, SatuManrique, Clara PMartin, RolandMartinelli, VittorioMason, DeborahMazibrada, GordonMcCabe, CristinMero, Inger-LiseMescheriakova, JuliaMoutsianas, LoukasMyhr, Kjell-MortenNagels, GuyNicholas, RichardNilsson, PetraPiehl, FredrikPirinen, MattiPrice, Siân EQuach, HongReunanen, MauriRobberecht, WimRobertson, Neil PRodegher, MariaemmaRog, DavidSalvetti, MarcoSchnetz-Boutaud, Nathalie CSellebjerg, FinnSelter, Rebecca CSchaefer, CatherineShaunak, SandipShen, LingShields, SimonSiffrin, VolkerSlee, MarkSorensen, Per SoelbergSorosina, MelissaSospedra, MireiaSpurkland, AnneStrange, AmySundqvist, EmilieThijs, VincentThorpe, JohnTicca, AnnaTienari, Penttivan Duijn, CorneliaVisser, Elizabeth MVucic, SteveWesterlind, HelgaWiley, James SWilkins, AlastairWilson, James FWinkelmann, JulianeZajicek, JohnZindler, EvaHaines, Jonathan LPericak-Vance, Margaret AIvinson, AdrianStewart, GraemeHafler, DavidHauser, Stephen LCompston, AlastairMcVean, GilDe Jager, PhilipSawcer, StephenMcCauley, Jacob L2014-07-072013Beecham, A. H., N. A. Patsopoulos, D. K. Xifara, M. F. Davis, A. Kemppinen, C. Cotsapas, T. S. Shahi, et al. 2013. “Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.” Nature genetics 45 (11): 10.1038/ng.2770. doi:10.1038/ng.2770. http://dx.doi.org/10.1038/ng.2770.1061-4036http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406971Using the ImmunoChip custom genotyping array, we analysed 14,498 multiple sclerosis subjects and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (p-value < 1.0 × 10-4). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 multiple sclerosis subjects and 26,703 healthy controls. In these 80,094 individuals of European ancestry we identified 48 new susceptibility variants (p-value < 5.0 × 10-8); three found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants in 103 discrete loci outside of the Major Histocompatibility Complex. With high resolution Bayesian fine-mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalogue of multiple sclerosis risk variants and illustrates the value of fine-mapping in the resolution of GWAS signals.en-USJournal Article2014-07-0710.1038/ng.2770