Zhou, PenghuiWucherpfennig, Kai2014-08-132014Zhou, Penghui, and Kai W Wucherpfennig. 2014. “Discovering cancer immunotherapy targets in vivo.” Oncoimmunology 3 (1): e28500. doi:10.4161/onci.28500. http://dx.doi.org/10.4161/onci.28500.2162-4011http://nrs.harvard.edu/urn-3:HUL.InstRepos:12717575A key challenge facing the cancer immunology field is the discovery of the most suitable targets for therapeutic intervention. We recently reported a novel RNA-interference (RNAi)-based approach for systematic discovery of such targets in the tumor microenvironment in vivo utilizing pooled shRNA libraries as a screening tool. Here, we discuss applying this unbiased method to develop innovative cancer therapeutics.en-UScancerT celltherapeutic targetsRNAi screentumor microenvironmentJournal Article2014-08-1310.4161/onci.28500