Ito-Amano, MidoriNakamura, YukioMorisaki, MikaHe, XinjunHayashi, MasanoriWatanapokasin, RamidaKato, Hiroyuki2014-11-032014Ito-Amano, Midori, Yukio Nakamura, Mika Morisaki, Xinjun He, Masanori Hayashi, Ramida Watanapokasin, and Hiroyuki Kato. 2014. “Temporal and Spatial Expression Patterns of Bone Morphogenetic Protein 3 in Developing Zebrafish.” The Open Rheumatology Journal 8 (1): 69-72. doi:10.2174/1874312901408010069. http://dx.doi.org/10.2174/1874312901408010069.1874-3129http://nrs.harvard.edu/urn-3:HUL.InstRepos:13347483Bone morphogenetic proteins (BMPs) are important elements in bone biology. We herein report the expression profiles of zebrafish bmp3 (zbmp3) as demonstrated by real-time PCR and in situ hybridization. The expression of zbmp3 was highly detectable by real-time PCR from 1 day post-fertilization (1 dpf) to 2 weeks post-fertilization (2 wpf) and peaked at 1 wpf. For in situ hybridization experiments, zbmp3 was expressed in the otic vesicle at 1 dpf, 2 dpf, 3 dpf, and 5 dpf. It was also expressed in the pharyngeal arches, including the opercle, branchiostegal ray, and pectoral fins, at 2 dpf. Our results suggest that zbmp3 may play an important role in the skeletal biology of developing zebrafish.en-USBmp3Expression patternsZebrafish.Journal Article2014-11-0310.2174/1874312901408010069