Buzon, Maria J.Sun, HongLi, ChunShaw, AmySeiss, KatherineOuyang, ZhengyuMartin-Gayo, EnriqueLeng, JinHenrich, Timothy J.Li, JonathanPereyra, FZurakowski, RyanWalker, BruceRosenberg, EricYu, Xu G.Lichterfeld, Mathias2014-09-082014Buzon, M. J., H. Sun, C. Li, A. Shaw, K. Seiss, Z. Ouyang, E. Martin-Gayo, et al. 2014. “HIV-1 persistence in CD4+ T cells with stem cell-like properties.” Nature medicine 20 (2): 139-142. doi:10.1038/nm.3445. http://dx.doi.org/10.1038/nm.3445.1078-8956http://nrs.harvard.edu/urn-3:HUL.InstRepos:12785806Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells (TSCM) harbor high per-cell levels of HIV-1 DNA, and make increasing contributions to the total viral CD4+ T cell reservoir over time. Moreover, phylogenetic studies suggested long-term persistence of viral quasispecies in CD4+ TSCM cells. Thus, HIV-1 may exploit stem cell characteristics of cellular immune memory to promote long-term viral persistence.en-USJournal Article2014-09-0810.1038/nm.3445