Tan, XuElledge, Stephen2014-11-032014Tan, Xu, and Stephen J Elledge. 2014. “When noise makes music: HIV reactivation with transcriptional noise enhancers.” Genome Medicine 6 (7): 55. doi:10.1186/s13073-014-0055-9. http://dx.doi.org/10.1186/s13073-014-0055-9.1756-994Xhttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13347653Reactivating latent HIV is key to depleting the virus reservoir in AIDS patients. A recent paper has described the rationale for and discovery of a new class of drugs - transcriptional noise enhancers - that can synergize with conventional transcription activators to more effectively reactivate latently infected T cells. As well as describing a promising new strategy in the bid to find a cure for AIDS, this study more broadly highlights the utility of exploring drug combinations in treatment of human disease.en-USJournal Article2014-11-0310.1186/s13073-014-0055-9