Liang, JunTeng, FeiLiu, XuekuiZou, CaiyanWang, YuDou, LianjunSun, ZilinQi, Lu2014-12-022014Liang, Jun, Fei Teng, Xuekui Liu, Caiyan Zou, Yu Wang, Lianjun Dou, Zilin Sun, and Lu Qi. 2014. “Synergistic effects of neck circumference and metabolic risk factors on insulin resistance: the Cardiometabolic Risk in Chinese (CRC) study.” Diabetology & Metabolic Syndrome 6 (1): 116. doi:10.1186/1758-5996-6-116. http://dx.doi.org/10.1186/1758-5996-6-116.1758-5996http://nrs.harvard.edu/urn-3:HUL.InstRepos:13454643Objectives: Recent studies have associated neck circumference (NC) with insulin resistance (IR). We examined whether such relation was modified by other metabolic risk factors. Methods: The study samples were from a community-based health examination survey in central China. A total of 2588 apparently healthy Chinese men and women were included. Results: Plasma levels of total cholesterol (TC), HDL-C, uric acid (UA) and diastolic blood pressure (DBP) were independently associated with NC after adjusted for age, sex, body mass index (BMI), waist circumference (WC) and hip circumference (HC) (P = 0.009, 0.001, 0.015 and 0.015, respectively). We observed significant interactions of NC with triglyceride (TG) and UA (all the p for interaction = 0.001) in relation to HOMA-IR. It appeared that the associations between NC and HOMA-IR were more evident in those with higher UA or TG level. Conclusions: Our data indicate that in apparently healthy Chinese adults, there were synergistic effects of UA, TG and neck circumference on insulin resistance.en-USInsulin resistanceNeck circumferenceUric acidTriglycerideSynergistic effectsJournal Article2014-12-0210.1186/1758-5996-6-116