Enciso-Mora, VictorBroderick, PeterMa, YussanneJarrett, Ruth FHjalgrim, HenrikHemminki, Karivan den Berg, AnkeOlver, BiancaLloyd, AmyDobbins, Sara ELightfoot, Tracyvan Leeuwen, Flora EFörsti, AstaDiepstra, ArjanBroeks, AnnegienVijayakrishnan, JayaramShield, LesleyLake, AnnetteMontgomery, DorothyRoman, EveEngert, Andreasvon Strandmann, Elke PoggeReiners, Katrin S.Nolte, Ilja MSmedby, Karin EAdami, Hans-OlovRussell, Nicola SGlimelius, BengtHamilton-Dutoit, Stephende Bruin, MariekeRyder, Lars PMolin, DanielSorensen, Karina MedenChang, Ellen TTaylor, MalcolmCooke, RosieHofstra, RobertWesters, Helgavan Wezel, Tomvan Eijk, RonaldAshworth, AlanRostgaard, KlausMelbye, MadsSwerdlow, Anthony JHoulston, Richard S2015-01-052014Enciso-Mora, V., P. Broderick, Y. Ma, R. F. Jarrett, H. Hjalgrim, K. Hemminki, A. van den Berg, et al. 2014. “A genome-wide association study of Hodgkin Lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21, and 10p14 (GATA3).” Nature genetics 42 (12): 1126-1130. doi:10.1038/ng.696. http://dx.doi.org/10.1038/ng.696.1061-4036http://nrs.harvard.edu/urn-3:HUL.InstRepos:13581091To identify predisposition loci for classical Hodgkin Lymphoma (cHL) we conducted a genome-wide association study of 589 cHL cases and 5,199 controls with validation in 4 independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL; odds ratio [OR]=1.22, Pcombined=1.91×10−8), 8q24.21 (rs2019960, PVT1; OR=1.33, Pcombined=1.26×10−13) and 10p14 (rs501764, GATA3; OR=1.25, Pcombined=7.05×10−8). Furthermore, we confirmed the role of the MHC in disease etiology by revealing a strong HLA association (rs6903608; OR=1.70, Pcombined=2.84×10−50). These data provide new insight into the pathogenesis of cHL.en-USJournal Article2015-01-0510.1038/ng.696