Pagnini, FrancescoBosma, ColinPhillips, DeborahLanger, Ellen2015-01-052014Pagnini, Francesco, Colin M Bosma, Deborah Phillips, and Ellen Langer. 2014. “Symptom changes in multiple sclerosis following psychological interventions: a systematic review.” BMC Neurology 14 (1): 222. doi:10.1186/s12883-014-0222-z. http://dx.doi.org/10.1186/s12883-014-0222-z.1471-2377http://nrs.harvard.edu/urn-3:HUL.InstRepos:13581126Background: Multiple Sclerosis is a disease of the central nervous system involving a variety of debilitating physical, sensory, cognitive and emotional symptoms. This literature review evaluated the impact of psychological interventions on the physiological symptoms associated with the illness. Methods: A systematic literature search was conducted using Medline, PsycINFO, Scopus, and the Cochrane Library databases, as well as reference lists. Relevant studies were selected and assessed according to a preset protocol. Results: The search produced 220 articles, with 22 meeting inclusion criteria for the review. A total of 5,705 subjects with Multiple Sclerosis were analyzed. Results from the included studies indicate a general improvement in both psychological and physiological outcomes following psychological treatment. The most highly influenced physical symptoms include fatigue, sleep disturbances, pain, and physical vitality. Conclusions: Findings from the review suggest a positive relationship between psychological interventions and physiological Multiple Sclerosis symptoms. Implications for future research are discussed.en-USMultiple sclerosisPsychological interventionsPhysical health outcomesMind/body connectionJournal Article2015-01-0510.1186/s12883-014-0222-z