Wei, NancyPan, JessicaPop-Busui, RodicaOthman, AlaaAlecu, IrinaHornemann, ThorstenEichler, Florian2015-01-052014Wei, Nancy, Jessica Pan, Rodica Pop-Busui, Alaa Othman, Irina Alecu, Thorsten Hornemann, and Florian S Eichler. 2014. “Altered sphingoid base profiles in type 1 compared to type 2 diabetes.” Lipids in Health and Disease 13 (1): 161. doi:10.1186/1476-511X-13-161. http://dx.doi.org/10.1186/1476-511X-13-161.1476-511Xhttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13581221Background: Sphingolipids are increasingly recognized to play a role in insulin resistance and diabetes. Recently we reported significant elevations of 1-deoxysphingolipids (1-deoxySL) - an atypical class of sphingolipids in patients with metabolic syndrome (MetS) and diabetes type 2 (T2DM). It is unknown whether 1-deoxySL in patients with diabetes type 1 (T1DM) are similarly elevated. Findings: We analyzed the long chain base profile by LC-MS after hydrolyzing the N-acyl and O-linked headgroups in plasma from individuals with T1DM (N = 27), T2DM (N = 30) and healthy controls (N = 23). 1-deoxySLs were significantly higher in the groups with T2DM but not different between T1DM and controls. In contrast to patients with T2DM, 1-deoxSL levels are not elevated in T1DM. Conclusions: Our study indicates that the 1-deoxySL formation is not per-se caused by hyperglycemia but rather specifically associated with metabolic changes in T2DM, such as elevated triglyceride levels. Electronic supplementary material The online version of this article (doi:10.1186/1476-511X-13-161) contains supplementary material, which is available to authorized users.en-USAtypical sphingolipidsBiomarkerDeoxysphingolipidsMetabolic syndromeType 2 diabetes mellitusType 1 diabetes mellitusJournal Article2015-01-0510.1186/1476-511X-13-161