Wagholikar, KavishwarMandel, JoshuaKlann, Jeffery GWattanasin, NichMendis, MichaelChute, Christopher GMandl, KennethMurphy, Shawn2017-05-012016Wagholikar, Kavishwar B, Joshua C Mandel, Jeffery G Klann, Nich Wattanasin, Michael Mendis, Christopher G Chute, Kenneth D Mandl, and Shawn N Murphy. 2016. “SMART-on-FHIR implemented over i2b2.” Journal of the American Medical Informatics Association : JAMIA 24 (2): 398-402. doi:10.1093/jamia/ocw079. http://dx.doi.org/10.1093/jamia/ocw079.http://nrs.harvard.edu/urn-3:HUL.InstRepos:32630441We have developed an interface to serve patient data from Informatics for Integrating Biology and the Bedside (i2b2) repositories in the Fast Healthcare Interoperability Resources (FHIR) format, referred to as a SMART-on-FHIR cell. The cell serves FHIR resources on a per-patient basis, and supports the “substitutable” modular third-party applications (SMART) OAuth2 specification for authorization of client applications. It is implemented as an i2b2 server plug-in, consisting of 6 modules: authentication, REST, i2b2-to-FHIR converter, resource enrichment, query engine, and cache. The source code is freely available as open source. We tested the cell by accessing resources from a test i2b2 installation, demonstrating that a SMART app can be launched from the cell that accesses patient data stored in i2b2. We successfully retrieved demographics, medications, labs, and diagnoses for test patients. The SMART-on-FHIR cell will enable i2b2 sites to provide simplified but secure data access in FHIR format, and will spur innovation and interoperability. Further, it transforms i2b2 into an apps platform.en-USDatabase management systemsinformation storage and retrievalmedical informaticssystems integrationclinical decision supportuser-computer interfaceJournal Article2017-05-0110.1093/jamia/ocw079