Goode, Ellen LChenevix-Trench, GeorgiaSong, HonglinRamus, Susan JNotaridou, MariaLawrenson, KateWidschwendter, MartinVierkant, Robert ALarson, Melissa CKjaer, Susanne KBirrer, Michael J.Berchuck, AndrewSchildkraut, JoellenTomlinson, IanKiemeney, Lambertus ACook, Linda SGronwald, JacekGarcia-Closas, MontserratGore, Martin ECampbell, IanWhittemore, Alice SSutphen, RebeccaPhelan, CatherineAnton-Culver, HodaPearce, Celeste LeighLambrechts, DietherRossing, Mary AnneChang-Claude, JennyMoysich, Kirsten BGoodman, Marc TDörk, ThiloNevanlinna, HeliNess, Roberta BRafnar, ThorunnHogdall, ClausHogdall, EstridFridley, Brooke LCunningham, Julie MSieh, WeivaMcGuire, ValerieGodwin, Andrew KCramer, DanielHernandez, DenaLevine, DouglasLu, KarenIversen, Edwin SPalmieri, Rachel THoulston, Richardvan Altena, Anne MAben, Katja K HMassuger, Leon F A GBrooks-Wilson, AngelaKelemen, Linda ELe, Nhu DJakubowska, AnnaLubinski, JanMedrek, KrzysztofStafford, AnneEaston, Douglas FTyrer, JonathanBolton, Kelly LHarrington, PatriciaEccles, DianaChen, AnnMolina, Ashley NDavila, Barbara NArango, HectorTsai, Ya-YuChen, ZhihuaRisch, Harvey AMcLaughlin, JohnNarod, Steven AZiogas, ArgyriosBrewster, WendyGentry-Maharaj, AleksandraMenon, UshaWu, Anna HStram, Daniel OPike, Malcolm CBeesley, JonathanWebb, Penelope MChen, XiaoqingEkici, Arif BThiel, Falk CBeckmann, Matthias WYang, HannahWentzensen, NicolasLissowska, JolantaFasching, Peter ADespierre, EvelynAmant, FredericVergote, IgnaceDoherty, JenniferHein, RebeccaWang-Gohrke, ShanLurie, GalinaCarney, Michael EThompson, Pamela JRunnebaum, IngoHillemanns, PeterDürst, MatthiasAntonenkova, NataliaBogdanova, NataliaLeminen, ArtoButzow, RalfHeikkinen, TuomasStefansson, KariSulem, PatrickBesenbacher, SörenSellers, Thomas AGayther, Simon APharoah, Paul D P2016-06-162010Goode, Ellen L, Georgia Chenevix-Trench, Honglin Song, Susan J Ramus, Maria Notaridou, Kate Lawrenson, Martin Widschwendter, et al. 2010. “A Genome-Wide Association Study Identifies Susceptibility Loci for Ovarian Cancer at 2q31 and 8q24.” Nat Genet 42 (10) (September 19): 874–879. doi:10.1038/ng.668.1061-4036http://nrs.harvard.edu/urn-3:HUL.InstRepos:27332764Ovarian cancer (OC) accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance OC susceptibility genes, we conducted a genome-wide association study (GWAS) of 507,094 SNPs in 1,768 cases and 2,354 controls, with follow-up of 21,955 SNPs in 4,162 cases and 4,810 controls, leading to the identification of a confirmed susceptibility locus at 9p22 (BNC2)1. Here, we report on nine additional candidate loci (p≤10-4), identified after stratifying cases by histology, genotyped in an additional 4,353 cases and 6,021 controls. Two novel susceptibility loci with p≤5×10-8 were confirmed (8q24, p=8.0×10-15 and 2q31, p=3.8×10-14); two additional loci were also identified that approached genome-wide significance (3q25, p=7.1×10-8 and 17q21, p=1.4×10-7). The associations with serous OC were generally stronger than other subtypes. Analysis of HOXD1, MYC, TiPARP, and SKAP1 at these loci, and BNC2 at 9p22, supports a functional role for these genes in OC development.en-USJournal Article2016-06-1610.1038/ng.668