Weighing Evidence from Mendelian Randomization—Early-Life Obesity as a Causal Factor in Multiple Sclerosis?

Ascherio, AlbertoMunger, Kassandra2016-08-092016Ascherio, Alberto, and Kassandra L. Munger. 2016. “Weighing Evidence from Mendelian Randomization—Early-Life Obesity as a Causal Factor in Multiple Sclerosis?” PLoS Medicine 13 (6): e1002054. doi:10.1371/journal.pmed.1002054. http://dx.doi.org/10.1371/journal.pmed.1002054.1549-1277http://nrs.harvard.edu/urn-3:HUL.InstRepos:27822311In this Perspective, Alberto Ascherio and Kassandra Munger discuss the implications of Richards and colleagues' study exploring the role of early-life obesity in risk of multiple sclerosis.en-USBiology and Life SciencesPhysiologyPhysiological ParametersBody WeightObesityMedicine and Health SciencesBody Mass IndexClinical MedicineClinical ImmunologyAutoimmune DiseasesMultiple SclerosisImmunologyNeurologyDemyelinating DisordersNeurodegenerative DiseasesComputational BiologyGenome AnalysisGenome-Wide Association StudiesGeneticsGenomicsHuman GeneticsEpidemiologyGenetic EpidemiologyPharmaceuticsDose Prediction MethodsObservational StudiesProspective StudiesWeighing Evidence from Mendelian Randomization—Early-Life Obesity as a Causal Factor in Multiple Sclerosis?Journal Article2016-08-0910.1371/journal.pmed.1002054