Qi, QibinDowner, MaryKilpeläinen, Tuomas O.Taal, H. RobBarton, Sheila J.Ntalla, IoannaStandl, MarieBoraska, VesnaHuikari, VilleKiefte-de Jong, Jessica C.Körner, AntjeLakka, Timo A.Liu, GaifenMagnusson, JessicaOkuda, MasayukiRaitakari, OlliRichmond, RebeccaScott, Robert A.Bailey, Mark E.S.Scheuermann, KathrinHolloway, John W.Inskip, HazelIsasi, Carmen R.Mossavar-Rahmani, YasminJaddoe, Vincent W.V.Laitinen, JaanaLindi, VirpiMelén, ErikPitsiladis, YannisPitkänen, NiinaSnieder, HaroldHeinrich, JoachimTimpson, Nicholas J.Wang, TaoYuji, HinodaZeggini, EleftheriaDedoussis, George V.Kaplan, Robert C.Wylie-Rosett, JudithLoos, Ruth J.F.Hu, FrankQi, Lu2016-08-092015Qi, Q., M. K. Downer, T. O. Kilpeläinen, H. R. Taal, S. J. Barton, I. Ntalla, M. Standl, et al. 2015. “Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents.” Diabetes 64 (7): 2467-2476. doi:10.2337/db14-1629. http://dx.doi.org/10.2337/db14-1629.0012-1797http://nrs.harvard.edu/urn-3:HUL.InstRepos:27822322The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for FTO variation in influencing food intake. We conducted a combined analysis of 16,094 boys and girls aged 1–18 years from 14 studies to examine the following: 1) the association between the FTO rs9939609 variant (or a proxy) and total energy and macronutrient intake; and 2) the interaction between the FTO variant and dietary intake, and the effect on BMI. We found that the BMI-increasing allele (minor allele) of the FTO variant was associated with increased total energy intake (effect per allele = 14.3 kcal/day [95% CI 5.9, 22.7 kcal/day], P = 6.5 × 10−4), but not with protein, carbohydrate, or fat intake. We also found that protein intake modified the association between the FTO variant and BMI (interactive effect per allele = 0.08 SD [0.03, 0.12 SD], P for interaction = 7.2 × 10−4): the association between FTO genotype and BMI was much stronger in individuals with high protein intake (effect per allele = 0.10 SD [0.07, 0.13 SD], P = 8.2 × 10−10) than in those with low intake (effect per allele = 0.04 SD [0.01, 0.07 SD], P = 0.02). Our results suggest that the FTO variant that confers a predisposition to higher BMI is associated with higher total energy intake, and that lower dietary protein intake attenuates the association between FTO genotype and adiposity in children and adolescents.en-USJournal Article2016-08-0910.2337/db14-1629