Treasure, Graham C.Aga, EvgeniaBosch, RonaldMellors, John W.Kuritzkes, DanielPara, MichaelGandhi, RajeshLi, Jonathan2016-08-092016Treasure, Graham C., Evgenia Aga, Ronald J. Bosch, John W. Mellors, Daniel R. Kuritzkes, Michael Para, Rajesh T. Gandhi, and Jonathan Z. Li. 2016. “Brief Report: Relationship Among Viral Load Outcomes in HIV Treatment Interruption Trials.” Journal of Acquired Immune Deficiency Syndromes (1999) 72 (3): 310-313. doi:10.1097/QAI.0000000000000964. http://dx.doi.org/10.1097/QAI.0000000000000964.1525-4135http://nrs.harvard.edu/urn-3:HUL.InstRepos:27822404Abstract: Viral load (VL) rebound timing and set point were analyzed in 235 participants undergoing analytic treatment interruption (ATI) in 6 AIDS Clinical Trials Group studies. There was no significant association between rebound timing and ATI VL set point for those who rebounded ≤12 weeks. VL set points were lower in participants with rebound >12 weeks (P < 0.001) and participants treated during early infection (P < 0.001). Pre-antiretroviral therapy VL correlated with set point, though 68% of participants had a set point lower than pre-antiretroviral therapy VL. These results illustrate complex relationships between post-ATI virologic outcomes and the potential presence of biological factors mediating rebound timing and set point.en-USHIVtreatment interruptionset pointviral reboundoutcomeJournal Article2016-08-0910.1097/QAI.0000000000000964