Merritt, Melissa A.Kotsopoulos, JoanneCramer, DanielHankinson, SusanTerry, KathrynTworoger, Shelley2016-06-152012Merritt, Melissa A., Joanne Kotsopoulos, Daniel W. Cramer, Susan E. Hankinson, Kathryn L. Terry, and Shelley S. Tworoger. 2012. “Duarte Galactose-1-Phosphate Uridyl Transferase Genotypes Are Not Associated with Ovarian Cancer Risk.” Fertility and Sterility 98 (3) (September): 687–691. doi:10.1016/j.fertnstert.2012.05.045.0015-0282http://nrs.harvard.edu/urn-3:HUL.InstRepos:27332427Objective To investigate whether Galactose-1-phosphate uridyl transferase (GALT) variant genotypes were associated with epithelial ovarian cancer risk and to determine if this association was modified by lactose intake. Design two prospective cohort studies and a case-control study. Setting Academic institution. Patient(s) 992 cases and 1050 population-based controls from a New England case-control study and 240 cases and 900 controls from the Nurses’ Health Studies. Intervention(s) None. Main Outcome Measure(s) Genotyping of the N314D variant and the 4-bp deletion (-119delGTCA) of GALT using the Taqman 5′ nuclease assay. Duarte1 (D1) genotype individuals have a missense mutation (N314D) associated with normal GALT activity unless it occurs together with an associated 4-bp deletion leading to reduced GALT activity (Duarte2 or D2). Result(s) Logistic regression analysis identified no association between D1/D2 genotypes and ovarian cancer risk (pooled RR, 1.1 (95% CI, 0.8–1.5) for D1 and 1.0 (95% CI, 0.7–1.4) for D2). We did not observe a significant interaction between D1 and D2 genotypes in analyses stratified by level of lactose intake (Pinteraction ≥ 0.3). Conclusion(s) D1 and D2 genotypes do not appear to play a role in the association between galactose intake, possible ovarian dysfunction and the link with ovarian cancer.en-USDuarte GALTovarian cancerdairy foodslactoseJournal Article2016-06-1510.1016/j.fertnstert.2012.05.045