Labarca, GonzaloAravena, CarlosOrtega, FranciscoArenas, AlexMajid, AdnanFolch, ErikMehta, Hiren J.Jantz, Michael A.Fernandez-Bussy, Sebastian2016-12-022016Labarca, Gonzalo, Carlos Aravena, Francisco Ortega, Alex Arenas, Adnan Majid, Erik Folch, Hiren J. Mehta, Michael A. Jantz, and Sebastian Fernandez-Bussy. 2016. “Minimally Invasive Methods for Staging in Lung Cancer: Systematic Review and Meta-Analysis.” Pulmonary Medicine 2016 (1): 1024709. doi:10.1155/2016/1024709. http://dx.doi.org/10.1155/2016/1024709.2090-1836http://nrs.harvard.edu/urn-3:HUL.InstRepos:29626121Introduction:. Endobronchial ultrasound (EBUS) is a procedure that provides access to the mediastinal staging; however, EBUS cannot be used to stage all of the nodes in the mediastinum. In these cases, endoscopic ultrasound (EUS) is used for complete staging. Objective. To provide a synthesis of the evidence on the diagnostic performance of EBUS + EUS in patients undergoing mediastinal staging. Methods. Systematic review and meta-analysis to evaluate the diagnostic yield of EBUS + EUS compared with surgical staging. Two researchers performed the literature search, quality assessments, data extractions, and analyses. We produced a meta-analysis including sensitivity, specificity, and likelihood ratio analysis. Results. Twelve primary studies (1515 patients) were included; two were randomized controlled trials (RCTs) and ten were prospective trials. The pooled sensitivity for combined EBUS + EUS was 87% (CI 84–89%) and the specificity was 99% (CI 98–100%). For EBUS + EUS performed with a single bronchoscope group, the sensitivity improved to 88% (CI 83.1–91.4%) and specificity improved to 100% (CI 99-100%). Conclusion. EBUS + EUS is a highly accurate and safe procedure. The combined procedure should be considered in selected patients with lymphadenopathy noted at stations that are not traditionally accessible with conventional EBUS.en-USJournal Article2016-12-0210.1155/2016/1024709