Lain, Aurelio HernandezLieberman, Andrew P.Pfannl, RolfHedley-Whyte, E.2017-05-172010Lain, Aurelio Hernandez, Andrew P. Lieberman, Rolf Pfannl, and E. Tessa Hedley-Whyte. 2010. “Nodular Bilateral Amygdala Degeneration in Demented Individuals.” Acta Neuropathologica 120 (5) (September 14): 683–688. doi:10.1007/s00401-010-0745-3.0001-6322http://nrs.harvard.edu/urn-3:HUL.InstRepos:32697821Among more than 2050 brains in our Alzheimer disease brain banks we came across three brains with well demarcated indurated white-yellow nodules in the amygdalas. Microscopically, these nodules were composed of numerous lipid-laden macrophages located in the central region surrounded by an eosinophilic hyaline-like material with minimal reactive gliosis in the periphery. Neurons within these lesions had a normal appearance but were moderately decreased in number. Beta-amyloid, tau and alpha-synuclein immunostaining revealed no abnormal deposits within the nodules. The three patients had long histories of dementia (one linked to a presenilin-1 mutation). The neuropathological diagnoses were Alzheimer disease in two of them and an unclassified tauopathy with argyrophilic grains in the third.en-USAmygdalaAlzheimer diseaseNeurodegenerationJournal Article2017-03-2220102017-05-1710.1007/s00401-010-0745-3