Mullarky, EdouardLairson, Luke L.Cantley, Lewis C.Lyssiotis, Costas A.2017-04-062016Mullarky, Edouard, Luke L. Lairson, Lewis C. Cantley, and Costas A. Lyssiotis. 2016. “A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase.” Molecular & Cellular Oncology 3 (4): e1164280. doi:10.1080/23723556.2016.1164280. http://dx.doi.org/10.1080/23723556.2016.1164280.http://nrs.harvard.edu/urn-3:HUL.InstRepos:32072062ABSTRACT Serine metabolism is likely to play a critical role in cancer cell growth. A recent study reports the identification of a novel small-molecule inhibitor of serine synthesis that targets 3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme of the serine synthesis pathway, and selectively abrogates the proliferation of PHGDH overexpressing breast cancer cells.en-US3-phosphoglycerate dehydrogenasecancer metabolismPHGDHserineJournal Article2017-04-0610.1080/23723556.2016.1164280