Von Keudell, ArvindThornhill, ThomasKatz, JeffreyLosina, Elena2017-02-182016Von Keudell, Arvind G., Thomas S. Thornhill, Jeffrey N. Katz, and Elena Losina. 2016. “Mortality Risk Assessment of Total Knee Arthroplasty and Related Surgery After Percutaneous Coronary Intervention.” The Open Orthopaedics Journal 10 (1): 706-716. doi:10.2174/1874325001610010706. http://dx.doi.org/10.2174/1874325001610010706.1874-3250http://nrs.harvard.edu/urn-3:HUL.InstRepos:30371160Background: The optimal antiplatelet therapy (APT) treatment strategy after Coronary Artery Stenting (CAS) in non-cardiac surgery, such as total knee arthroplasty (TKA) or urgent TKA-related surgery remains unknown. Methods: We built a decision tree model to examine the mortality outcomes of two alternative strategies for APT after CAS use in the perioperative period namely, continuous use and discontinuation. Results: If surgery was performed in the first month after CAS placement, discontinuing APT led to an estimated 30-day post TKA mortality of 10.5%, compared to 1.0% in a strategy with continuous APT use. Mortality with both strategies decreased with longer intervals. Conclusion: Our model demonstrated that APT discontinuation in patients undergoing TKA or urgent TKA related surgery after CAS placement might lead to greater 30-day mortality up to one year.en-USClopidogrelCoronary stentingMortalityPlavixRevision total knee arthroplastyTotal knee arthroplastyJournal Article2017-02-1810.2174/1874325001610010706