Hulten, Edward A.Bittencourt, Marcio SommerPreston, RyanSingh, AvinainderRomagnolli, CarlaGhoshhajra, BrianShah, RaviAbbasi, SiddiqueAbbara, SuhnyNasir, KhurramBlaha, MichaelHoffmann, UdoDi Carli, MarceloBlankstein, Ron2017-02-182017Hulten, E. A., M. S. Bittencourt, R. Preston, A. Singh, C. Romagnolli, B. Ghoshhajra, R. Shah, et al. 2017. “Obesity, metabolic syndrome and cardiovascular prognosis: from the Partners coronary computed tomography angiography registry.” Cardiovascular Diabetology 16 (1): 14. doi:10.1186/s12933-017-0496-8. http://dx.doi.org/10.1186/s12933-017-0496-8.1475-2840http://nrs.harvard.edu/urn-3:HUL.InstRepos:30371161Objective: To investigate the relationship among body mass index (BMI), cardiometabolic risk and coronary artery disease (CAD) among patients undergoing coronary computed tomography angiography (CTA). Methods: Retrospective cohort study of 1118 patients, who underwent coronary CTA at two centers from September 2004 to October 2011. Coronary CTA were categorized as normal, nonobstructive CAD (<50%), or obstructive CAD (≥50%) in addition to segment involvement (SIS) and stenosis scores. Extensive CAD was defined as SIS > 4. Association of BMI with cardiovascular prognosis was evaluated using multivariable fractional polynomial models. Results: Mean age of the cohort was 57 ± 13 years with median follow-up of 3.2 years. Increasing BMI was associated with MetS (OR 1.28 per 1 kg/m2, p < 0.001) and burden of CAD on a univariable basis, but not after multivariable adjustment. Prognosis demonstrated a J-shaped relationship with BMI. For BMI from 20–39.9 kg/m2, after adjustment for age, gender, and smoking, MetS (HR 2.23, p = 0.009) was more strongly associated with adverse events. Conclusions: Compared to normal BMI, there was an increased burden of CAD for BMI > 25 kg/m2. Within each BMI category, metabolically unhealthy patients had greater extent of CAD, as measured by CCTA, compared to metabolically healthy patients.en-USObesityMetabolic syndromeCoronary computed tomography angiographyCoronary artery diseasePrognosisCohortJournal Article2017-02-1810.1186/s12933-017-0496-8