Page, KimberlyMirzazadeh, AliRice, Thomas M.Grebely, JasonKim, ArthurCox, Andrea L.Morris, Meghan D.Hellard, MargaretBruneau, JulieShoukry, Naglaa H.Dore, Gregory J.Maher, LisaLloyd, Andrew R.Lauer, GeorgPrins, MariaMcGovern, Barbara H.2016-04-012016Page, K., A. Mirzazadeh, T. M. Rice, J. Grebely, A. Y. Kim, A. L. Cox, M. D. Morris, et al. 2016. “Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.” Open Forum Infectious Diseases 3 (1): ofw024. doi:10.1093/ofid/ofw024. http://dx.doi.org/10.1093/ofid/ofw024.2328-8957http://nrs.harvard.edu/urn-3:HUL.InstRepos:26318503Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease.en-USacute infectionalanine aminotransferasehepatitis C virusIFNL4jaundiceJournal Article2016-04-0110.1093/ofid/ofw024