A Critical Reappraisal of Prolonged Neutropenia as a Risk Factor for Invasive Pulmonary Aspergillosis

Abers, MichaelGhebremichael, MusieTimmons, Allison K.Warren, H.Poznansky, MarkVyas, Jatin2016-04-012016Abers, Michael S., Musie S. Ghebremichael, Allison K. Timmons, H. Shaw Warren, Mark C. Poznansky, and Jatin M. Vyas. 2016. “A Critical Reappraisal of Prolonged Neutropenia as a Risk Factor for Invasive Pulmonary Aspergillosis.” Open Forum Infectious Diseases 3 (1): ofw036. doi:10.1093/ofid/ofw036. http://dx.doi.org/10.1093/ofid/ofw036.2328-8957http://nrs.harvard.edu/urn-3:HUL.InstRepos:26318538Prolonged neutropenia is generally thought to be the major factor for invasive pulmonary aspergillosis (IPA). In the present study, we characterize the frequency, severity, and duration of neutropenia that immediately precedes IPA. Prolonged neutropenia was identified in only one third of all IPA cases and occurred exclusively in hematologic patients.en-USimmunosuppressioninvasive aspergillosisinvasive fungal infectionneutropeniaA Critical Reappraisal of Prolonged Neutropenia as a Risk Factor for Invasive Pulmonary AspergillosisJournal Article2016-04-0110.1093/ofid/ofw036