Mohan, AkanshaRoberto, Aaron J.Mohan, AbhishekLorenzo, AileenJones, KathrynCarney, Martin J.Liogier-Weyback, LuisHwang, SoonjoLapidus, Kyle A.B.2016-04-012016Mohan, Akansha, Aaron J. Roberto, Abhishek Mohan, Aileen Lorenzo, Kathryn Jones, Martin J. Carney, Luis Liogier-Weyback, Soonjo Hwang, and Kyle A.B. Lapidus. 2016. “The Significance of the Default Mode Network (DMN) in Neurological and Neuropsychiatric Disorders: A Review.” The Yale Journal of Biology and Medicine 89 (1): 49-57.0044-0086http://nrs.harvard.edu/urn-3:HUL.InstRepos:26318604The relationship of cortical structure and specific neuronal circuitry to global brain function, particularly its perturbations related to the development and progression of neuropathology, is an area of great interest in neurobehavioral science. Disruption of these neural networks can be associated with a wide range of neurological and neuropsychiatric disorders. Herein we review activity of the Default Mode Network (DMN) in neurological and neuropsychiatric disorders, including Alzheimer’s disease, Parkinson’s disease, Epilepsy (Temporal Lobe Epilepsy - TLE), attention deficit hyperactivity disorder (ADHD), and mood disorders. We discuss the implications of DMN disruptions and their relationship to the neurocognitive model of each disease entity, the utility of DMN assessment in clinical evaluation, and the changes of the DMN following treatment.en-USDefault Mode NetworkResting State Functional Magnetic Resonance ImagingAlzheimer’s diseaseParkinson’s diseaseTemporal Lobe Epilepsymood disorderattention deficit hyperactivity disorderJournal Article2016-04-01