Amparo, FranciscoSchaumberg, Debra A.Dana, Reza2018-02-202015Amparo, Francisco, Debra A. Schaumberg, and Reza Dana. 2015. “Comparison of Two Questionnaires for Dry Eye Symptom Assessment.” Ophthalmology 122 (7) (July): 1498–1503. doi:10.1016/j.ophtha.2015.02.037.0161-6420http://nrs.harvard.edu/urn-3:HUL.InstRepos:34854272Purpose The aim of this study was to compare patient reported symptoms of dry eye disease (DED) as assessed by the Ocular Surface Disease Index (OSDI©), a 12-item symptom frequency-based questionnaire, and the Symptom Assessment iN Dry Eye (SANDE), a 2-item frequency- and severity-based visual analog scale. Design Clinic-based evaluation of diagnostic test. Participants One hundred fourteen patients with dry eye disease. Methods Patients were administered the OSDI and SANDE questionnaires at baseline and follow-up visits to evaluate dry eye disease-related symptoms. The correlations between both questionnaires’ scores were evaluated using the Spearman coefficient and their clinical differences were assessed using the Bland-Altman analysis. Main Outcome Measures Baseline and follow-up visit OSDI and SANDE dry eye symptom scores. Results At the baseline visit, the OSDI and SANDE questionnaire scores significantly correlated (R = 0.64; P <0.001). Moreover, a significant correlation was found between changes in the OSDI and SANDE scores from baseline to follow-up visits (R = 0.47; P <0.001). A Bland-Altman analysis, after score normalization, revealed a difference (bias) of less than two centesimal units between the scores of the two questionnaires. Conclusions Data collected from the SANDE questionnaire showed a significant correlation and negligible score differences with those from the OSDI, suggesting that the SANDE visual analog scale-based questionnaire has the potential to provide clinicians with a short, quick and reliable measure for DED symptoms.en-USJournal Article2017-06-1920152018-02-2010.1016/j.ophtha.2015.02.037