Chen, OuRiedemann, LarsEtoc, FredHerrmann, HendrikCoppey, MathieuBarch, MariyaFarrar, ChristianZhao, JingBruns, Oliver T.Wei, HeGuo, PengCui, JianJensen, RussChen, YueHarris, Daniel K.Cordero, Jose M.Wang, ZhongwuJasanoff, AlanFukumura, DaiReimer, RudolphDahan, MaximeJain, RakeshBawendi, Moungi G.2015-05-042014Chen, O., L. Riedemann, F. Etoc, H. Herrmann, M. Coppey, M. Barch, C. T. Farrar, et al. 2014. “Magneto-Fluorescent Core-Shell Supernanoparticles.” Nature communications 5 (1): 5093. doi:10.1038/ncomms6093. http://dx.doi.org/10.1038/ncomms6093.2041-1723http://nrs.harvard.edu/urn-3:HUL.InstRepos:15034761Magneto-fluorescent particles have been recognized as an emerging class of materials that exhibit great potential in advanced applications. However, synthesizing such magneto-fluorescent nanomaterials that simultaneously exhibit uniform and tunable sizes, high magnetic content loading, maximized fluorophore coverage at the surface, and a versatile surface functionality has proven challenging. Here we report a simple approach for co-assembling magnetic nanoparticles with fluorescent quantum dots to form colloidal magneto-fluorescent supernanoparticles. Importantly, these supernanoparticles exhibit a superstructure consisting of a close packed magnetic nanoparticle “core” which is fully surrounded by a “shell” of fluorescent quantum dots. A thin layer of silica-coating provides high colloidal stability and biocompatiblity and a versatile surface functionality. We demonstrate that after surface pegylation, these silica-coated magneto-fluorescent supernanoparticles can be magnetically manipulated inside living cells while being optically tracked. Moreover, our silica-coated magneto-fluorescent supernanoparticles can also serve as an in vivo multi-photon and magnetic resonance dual-modal imaging probe.en-USJournal Article2015-05-0410.1038/ncomms6093