Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes

Weir, GordonBonner-Weir, Susan2017-03-282017Weir, Gordon C., and Susan Bonner-Weir. 2017. “Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes.” Frontiers in Genetics 8 (1): 2. doi:10.3389/fgene.2017.00002. http://dx.doi.org/10.3389/fgene.2017.00002.http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731635This commentary explores the hypothesis that when autoimmunity leads to a fall of beta cell mass during the progression of type 1 diabetes (T1D), rising glucose levels cause major changes in beta cell identity. This then leads to profound changes in secretory function and less well-understood changes in beta cell susceptibility to autoimmune destruction, which may influence of rate of progression of beta cell killing.en-USPerspectivebeta-cell biologytype 1 diabetesautoimmunitybeta-cell identitybeta-cell functionGlucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 DiabetesJournal Article2017-03-2810.3389/fgene.2017.00002