Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Imamura, MinakoTakahashi, AtsushiYamauchi, ToshimasaHara, KazuoYasuda, KazukiGrarup, NielsZhao, WeiWang, XuHuerta-Chagoya, AliciaHu, ChengMoon, SanghoonLong, JirongKwak, Soo HeonRasheed, AsifSaxena, RichaMa, Ronald C. W.Okada, YukinoriIwata, MinoruHosoe, JunShojima, NobuhiroIwasaki, MinakaFujita, HayatoSuzuki, KenDanesh, JohnJørgensen, TorbenJørgensen, Marit E.Witte, Daniel R.Brandslund, IvanChristensen, CramerHansen, TorbenMercader, Josep M.Flannick, JasonMoreno-Macías, HortensiaBurtt, Noël P.Zhang, RongKim, Young JinZheng, WeiSingh, Jai RupTam, Claudia H. T.Hirose, HiroshiMaegawa, HiroshiIto, ChikakoKaku, KoheiWatada, HirotakaTanaka, YasushiTobe, KazuyukiKawamori, RyuzoKubo, MichiakiCho, Yoon ShinChan, Juliana C. N.Sanghera, DharambirFrossard, PhilippePark, Kyong SooShu, Xiao-OuKim, Bong-JoFlorez, JoseTusié-Luna, TeresaJia, WeipingTai, E ShyongPedersen, OlufSaleheen, DanishMaeda, ShiroKadowaki, Takashi2016-04-012016Imamura, M., A. Takahashi, T. Yamauchi, K. Hara, K. Yasuda, N. Grarup, W. Zhao, et al. 2016. “Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.” Nature Communications 7 (1): 10531. doi:10.1038/ncomms10531. http://dx.doi.org/10.1038/ncomms10531.2041-1723http://nrs.harvard.edu/urn-3:HUL.InstRepos:26318622Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10−8), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.en-USGenome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetesJournal Article2016-04-0110.1038/ncomms10531