Malavolta, Eduardo AngeliDemange, Marco KawamuraGobbi, Riccardo GomesImamura, MartaFregni, Felipe2016-04-012011Malavolta, Eduardo Angeli, Marco Kawamura Demange, Riccardo Gomes Gobbi, Marta Imamura, and Felipe Fregni. 2011. “RANDOMIZED CONTROLLED CLINICAL TRIALS IN ORTHOPEDICS: DIFFICULTIES AND LIMITATIONS.” Revista Brasileira de Ortopedia 46 (4): 452-459. doi:10.1016/S2255-4971(15)30261-5. http://dx.doi.org/10.1016/S2255-4971(15)30261-5.2255-4971http://nrs.harvard.edu/urn-3:HUL.InstRepos:26318682Randomized controlled clinical trials (RCTs) are considered to be the gold standard for evidence-based medicine nowadays, and are important for directing medical practice through consistent scientific observations. Steps such as patient selection, randomization and blinding are fundamental for conducting a RCT, but some additional difficulties are presented in trials that involve surgical procedures, as is common in orthopedics. The aim of this article was to highlight and discuss some difficulties and possible limitations on RCTs within the field of surgery.en-USEvidence-Based MedicineOrthopedicsRandomized Controlled Trials as TopicComparative StudyJournal Article2016-04-0110.1016/S2255-4971(15)30261-5