Surendran, PraveenDrenos, FotiosYoung, RobinWarren, HelenCook, James PManning, AlisaGrarup, NielsSim, XuelingBarnes, Daniel RWitkowska, KateStaley, James RTragante, ViniciusTukiainen, TaruYaghootkar, HaniehMasca, NicholasFreitag, Daniel FFerreira, TeresaGiannakopoulou, OlgaTinker, AndrewHarakalova, MagdalenaMihailov, EvelinLiu, ChunyuKraja, Aldi TFallgaard Nielsen, SuneRasheed, AsifSamuel, MariaZhao, WeiBonnycastle, Lori LJackson, Anne UNarisu, NarisuSwift, Amy JSoutham, LorraineMarten, JonathanHuyghe, Jeroen RStančáková, AlenaFava, CristianoOhlsson, ThereseMatchan, AngelaStirrups, Kathleen EBork-Jensen, JetteGjesing, Anette PKontto, JukkaPerola, MarkusShaw-Hawkins, SusanHavulinna, Aki SZhang, HeDonnelly, Louise AGroves, Christopher JRayner, N WilliamNeville, Matt JRobertson, Neil RYiorkas, Andrianos MHerzig, Karl-HeinzKajantie, EeroZhang, WeihuaWillems, Sara MLannfelt, LarsMalerba, GiovanniSoranzo, NicoleTrabetti, ElisabettaVerweij, NiekEvangelou, EvangelosMoayyeri, AlirezaVergnaud, Anne-ClaireNelson, Christopher PPoveda, AlaitzVarga, Tibor VCaslake, Murielde Craen, Anton JMTrompet, StellaLuan, Jian’anScott, Robert AHarris, Sarah ELiewald, David CMMarioni, RiccardoMenni, CristinaFarmaki, Aliki-EleniHallmans, GöranRenström, FridaHuffman, Jennifer EHassinen, MaijaBurgess, StephenVasan, Ramachandran SFelix, Janine FUria-Nickelsen, MariaMalarstig, AndersReily, Dermot FHoek, MaartenVogt, ThomasLin, HonghuangLieb, WolfgangTraylor, MatthewMarkus, Hugh FHighland, Heather MJustice, Anne EMarouli, EiriniLindström, JaanaUusitupa, MattiKomulainen, PirjoLakka, Timo ARauramaa, RainerPolasek, OzrenRudan, IgorRolandsson, OlovFranks, PaulDedoussis, GeorgeSpector, Timothy DJousilahti, PekkaMännistö, SatuDeary, Ian JStarr, John MLangenberg, ClaudiaWareham, Nick JBrown, Morris JDominiczak, Anna FConnell, John MJukema, J WouterSattar, NaveedFord, IanPackard, Chris JEsko, TõnuMägi, ReedikMetspalu, Andresde Boer, Rudolf Avan der Meer, Petervan der Harst, PimGambaro, GiovanniIngelsson, ErikLind, Larsde Bakker, Paul IWNumans, Mattijs EBrandslund, IvanChristensen, CramerPetersen, Eva RBKorpi-Hyövälti, EevaOksa, HeikkiChambers, John CKooner, Jaspal SBlakemore, Alexandra IFFranks, SteveJarvelin, Marjo-RiittaHusemoen, Lise LLinneberg, AllanSkaaby, TeaThuesen, BetinaKarpe, FredrikTuomilehto, JaakkoDoney, Alex SFMorris, Andrew DPalmer, Colin NAHolmen, Oddgeir LingaasHveem, KristianWiller, Cristen JTuomi, TiinamaijaGroop, LeifKäräjämäki, AnneMariPalotie, AarnoRipatti, SamuliSalomaa, VeikkoAlam, Dewan SShafi Majumder, Abdulla alDi Angelantonio, EmanueleChowdhury, RajivMcCarthy, Mark IPoulter, NeilStanton, Alice VSever, PeterAmouyel, PhilippeArveiler, DominiqueBlankenberg, StefanFerrières, JeanKee, FrankKuulasmaa, KariMüller-Nurasyid, MartinaVeronesi, GiovanniVirtamo, JarmoDeloukas, PanosElliott, PaulZeggini, EleftheriaKathiresan, SekarMelander, OlleKuusisto, JohannaLaakso, MarkkuPadmanabhan, SandoshPorteous, DavidHayward, CarolineScotland, GenerationCollins, Francis SMohlke, Karen LHansen, TorbenPedersen, OlufBoehnke, MichaelStringham, Heather MFrossard, PhilippeNewton-Cheh, ChristopherTobin, Martin DNordestgaard, Børge GrønneCaulfield, Mark JMahajan, AnubhaMorris, Andrew PTomaszewski, MaciejSamani, Nilesh JSaleheen, DanishAsselbergs, Folkert WLindgren, Cecilia MDanesh, JohnWain, Louise VButterworth, Adam SHowson, Joanna MMMunroe, Patricia B2017-04-062016Surendran, P., F. Drenos, R. Young, H. Warren, J. P. Cook, A. K. Manning, N. Grarup, et al. 2016. “Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.” Nature genetics 48 (10): 1151-1161. doi:10.1038/ng.3654. http://dx.doi.org/10.1038/ng.3654.http://nrs.harvard.edu/urn-3:HUL.InstRepos:32072248High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to ~192,000 individuals, and used ~155,063 samples for independent replication. We identified 31 novel blood pressure or hypertension associated genetic regions in the general population, including three rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5mmHg/allele) than common variants. Multiple rare, nonsense and missense variant associations were found in A2ML1 and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention.en-USJournal Article2017-04-0610.1038/ng.3654