Savadjiev, PeterKindlmann, Gordon L.Bouix, SylvainShenton, MarthaWestin, Carl-Fredrik2016-09-232010Savadjiev P, Kindlmann GL, Bouix S, Shenton ME, Westin CF. 2010. Local white matter geometry from diffusion tensor gradients. Neuroimage 49, no. 4:3175-86. doi:10.1016/j.neuroimage.2009.10.0731053-8119http://nrs.harvard.edu/urn-3:HUL.InstRepos:28549001We introduce a mathematical framework for computing geometrical properties of white matter fibres directly from diffusion tensor fields. The key idea is to isolate the portion of the gradient of the tensor field corresponding to local variation in tensor orientation, and to project it onto a coordinate frame of tensor eigenvectors. The resulting eigenframe-centered representation then makes it possible to define scalar indices (or measures) that describe the local white matter geometry directly from the diffusion tensor field and its gradient, without requiring prior tractography. We derive new scalar indices of (1) fibre dispersion and (2) fibre curving, and we demonstrate them on synthetic and in vivo data. Finally, we illustrate their applicability to a group study on schizophrenia.en-USdiffusion tensor imagingmagnetic resonance imagingfibre geometryrotation tangentsfibre dispersionfibre curvingschizophreniaJournal Article2016-09-2310.1016/j.neuroimage.2009.10.073