Oxnard, GeoffreyPaweletz, CloudSholl, Lynette2017-05-182016Oxnard, Geoffrey R., Cloud P. Paweletz, and Lynette M. Sholl. 2016. “Genomic Analysis of Plasma Cell-Free DNA in Patients With Cancer.” JAMA Oncology (August 18). doi:10.1001/jamaoncol.2016.2835.2374-2437http://nrs.harvard.edu/urn-3:HUL.InstRepos:32705580The increased importance of cancer genotyping in guiding cancer treatment has created a need for efficient methods for genomic analysis of patients’ cancers. This increased dependence on DNA-based tumor genotyping assays (eg, sequencing, polymerase chain reaction [PCR], fluorescence in situ hybridization [FISH]) has triggered a growing interest in the analysis of free-floating DNA present in the blood of patients with cancer—plasma cell-free DNA (cfDNA). Sensitive PCR techniques together with high-throughput next-generation sequencing (NGS) technologies have evolved to a point where genetic analysis of cfDNA is possible.en-USJournal Article2017-08-1910.1001/jamaoncol.2016.2835