Sirasani, GopalTong, LiuchuanBalskus, Emily2017-07-202014Sirasani, Gopal, Liuchuan Tong, and Emily P. Balskus. 2014. “A Biocompatible Alkene Hydrogenation Merges Organic Synthesis with Microbial Metabolism.” Angewandte Chemie International Edition 53 (30) (June 10): 7785–7788. doi:10.1002/anie.201403148.1433-7851http://nrs.harvard.edu/urn-3:HUL.InstRepos:33470132Organic chemists and metabolic engineers use largely orthogonal technologies to construct essential small molecules like pharmaceuticals and commodity chemicals. While chemists have leveraged the unique capabilities of biological catalysts for small molecule production, metabolic engineers have not likewise integrated reactions from organic synthesis with the metabolism of living organisms. Here we report a method for alkene hydrogenation that utilizes a palladium catalyst and hydrogen gas generated directly by a living microorganism. This biocompatible transformation, which requires both catalyst and microbe and can be used on a preparative scale, represents a new strategy for chemical synthesis that combines organic chemistry and metabolic engineering.en-USbiocompatible chemistryhydrogenationmetabolismpalladiumcatalysisJournal Article2017-05-1120142017-07-2010.1002/anie.201403148