Waldman, AbrahamBalskus, Emily2017-07-202014Waldman, Abraham J., and Emily P. Balskus. 2014. “Lomaiviticin Biosynthesis Employs a New Strategy for Starter Unit Generation.” Organic Letters 16 (2) (January 17): 640–643. doi:10.1021/ol403714g.1523-7060http://nrs.harvard.edu/urn-3:HUL.InstRepos:33470127Lomaiviticin biosynthesis is thought to utilize a propionyl starter unit for a type II polyketide synthase (PKS). Discovery of the lomaiviticin (lom) biosynthetic gene cluster suggested an unusual method for starter unit generation involving a bifunctional acyltransferase/decarboxylase (AT/DC) thus far observed only in type I PKS pathways. In vitro biochemical characterization of AT/DC Lom62 confirmed its ability to generate a propionyl-acyl carrier protein (ACP), revealing a new role for this enzymatic activity within natural product biosynthesis.en-USJournal Article2017-05-1120142017-07-2010.1021/ol403714g