Kay, Euan R.Lee, JungminNocera, DanielBawendi, Moungi G.2017-07-182012Kay, Euan R., Jungmin Lee, Daniel G. Nocera, and Moungi G. Bawendi. 2012. “Conformational Control of Energy Transfer: A Mechanism for Biocompatible Nanocrystal-Based Sensors.” Angewandte Chemie International Edition 52 (4) (December 6): 1165–1169. doi:10.1002/anie.201207181.1433-7851http://nrs.harvard.edu/urn-3:HUL.InstRepos:33464245Fold-up fluorophore: A new paradigm for designing self-referencing fluorescent nanosensors is demonstrated by interfacing a pH-triggered molecular conformational switch with quantum dots. Analytedependent, large-amplitude conformational motion controls the distance between the nanocrystal energy donor and an organic FRET acceptor. The result is a fluorescence signal capable of reporting pH values from individual endosomes in living cells.en-USbiosensorsfluorescent probesquantum dotsmolecular devicesmolecular machinesJournal Article2017-05-1120122017-07-1810.1002/anie.201207181