Lemon, Christopher M.Curtin, Peter N.Somers, Rebecca C.Greytak, Andrew B.Lanning, Ryan M.Jain, RakeshBawendi, Moungi G.Nocera, Daniel2017-07-182014Lemon, Christopher M., Peter N. Curtin, Rebecca C. Somers, Andrew B. Greytak, Ryan M. Lanning, Rakesh K. Jain, Moungi G. Bawendi, and Daniel G. Nocera. 2014. “Metabolic Tumor Profiling with pH, Oxygen, and Glucose Chemosensors on a Quantum Dot Scaffold.” Inorganic Chemistry 53 (4) (February 17): 1900–1915. doi:10.1021/ic401587r.0020-1669http://nrs.harvard.edu/urn-3:HUL.InstRepos:33464242Acidity, hypoxia and glucose levels characterize the tumor microenvironment rendering pH, pO2 and pGlucose, respectively, important indicators of tumor health. To this end, understanding how these parameters change can be a powerful tool for the development of novel and effective therapeutics. We have designed optical chemosensors that feature a quantum dot and an analyte-responsive dye. These non-invasive chemosensors permit pH, oxygen, and glucose to be monitored dynamically within the tumor microenvironment by using multiphoton imaging.en-USJournal Article2017-05-1120132017-07-1810.1021/ic401587r