Myers, AndrewSeiple, IanHog, Daniel2018-01-242015Myers, Andrew, Ian Seiple, and Daniel Hog. 2015. “Practical Protocols for the Preparation of Highly Enantioenriched Silyl Ethers of (R)-3-Hydroxypentan-2-One, Building Blocks for the Synthesis of Macrolide Antibiotics.” Synlett 27 (01) (November 24): 57–60. doi:10.1055/s-0035-1560972.0936-5214http://nrs.harvard.edu/urn-3:HUL.InstRepos:34737220Methacrolein is transformed in three steps to (R)-3-tert-butyldiphenylsilyloxypentan-2-one or (R)-3-tert-butyldimethylsilyloxypentan-2-one, compounds which serve as building blocks for the construction of macrolide antibiotics. The route is practical, highly enantioselective, and easily scaled.en-USenantioselective synthesismacrolide antibioticsasymmetric additionorganozinc reagentNugent protocolJournal Article2017-05-12201610.1055/s-0035-1560972