Kunjachan, SijumonDetappe, AlexandreKumar, RajivIreland, ThomasCameron, LisaBiancur, DouglasMotto-Ros, VincentSancey, LucieSridhar, SrinivasMakrigiorgos, GerassimosBerbeco, Ross2018-05-142015Kunjachan, Sijumon, Alexandre Detappe, Rajiv Kumar, Thomas Ireland, Lisa Cameron, Douglas E. Biancur, Vincent Motto-Ros, et al. 2015. “Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy.” Nano Lett. 15 (11) (November 11): 7488–7496. doi:10.1021/acs.nanolett.5b03073.1530-6984http://nrs.harvard.edu/urn-3:HUL.InstRepos:36875791More than 50% of all cancer patients receive radiation therapy. The clinical delivery of curative radiation dose is strictly restricted by the proximal healthy tissues. We propose a dual-targeting strategy using vessel-targeted-radiosensitizing gold nanoparticles and conformal-image guided radiation therapy to specifically amplify damage in the tumor neoendothelium. The resulting tumor vascular disruption substantially improved the therapeutic outcome and subsidized the radiation/nanoparticle toxicity, extending its utility to intransigent or nonresectable tumors that barely respond to standard therapies.en-USimage-guided radiation therapyendothelial radiation damagetumor vascular disruptiongold nanoparticlesJournal Article2016-01-16Kunjachan S , Detappe A , Kumar R , Ireland T , Cameron L , Biancur DE , Motto-Ros V , Sancey L , Sridhar S , Makrigiorgos GM , Berbeco RI2018-05-1410.1021/acs.nanolett.5b03073