Frumin, MelissaGolland, PolinaKikinis, RonHirayasu, YoshioSalisbury, Dean F.Hennen, JohnDickey, ChandleeAnderson, MarkJolesz, FerencGrimson, W. Eric L.McCarley, Robert WilliamShenton, Martha2016-09-152002Frumin, Melissa, Polina Golland, Ron Kikinis, Yoshio Hirayasu, Dean F. Salisbury, John Hennen, Chandlee C. Dickey, et al. 2002. Shape Differences in the Corpus Callosum in First-Episode Schizophrenia and First-Episode Psychotic Affective Disorder. AJP 159, no. 5: 866–868. doi:10.1176/appi.ajp.159.5.866.0002-953Xhttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28520524Objective: The corpus callosum, the largest white matter tract in the brain, is a midline structure associated with the formation of the hippocampus, septum pellucidum, and cingulate cortex, which have been implicated in the pathogenesis of schizophrenia. Corpus callosum shape deformation, therefore, may reflect a midline neurodevelopmental abnormality. Method: Corpus callosum area and shape were analyzed in 14 first-episode psychotic patients with schizophrenia, 19 first-episode psychotic patients with affective disorder, and 18 normal comparison subjects. Results: No statistically significant corpus callosum area differences between groups were found, but there were differences in the structure’s shape between the patients with schizophrenia and the comparison subjects. A correlation between width and angle of the corpus callosum was found in patients with affective disorder. Conclusions: Corpus callosum shape abnormalities in first-episode psychotic patients with schizophrenia may reflect a midline neurodevelopmental abnormality.en-USJournal Article2016-09-1510.1176/appi.ajp.159.5.866