Baptista, Natalie M.Christensen, KurtCarere, Deanna AlexisBroadley, Simon A.Roberts, J. ScottGreen, Robert2016-11-182015Baptista, Natalie M., Kurt D. Christensen, Deanna Alexis Carere, Simon A. Broadley, J. Scott Roberts, and Robert C. Green. 2015. “Adopting Genetics: Motivations and Outcomes of Personal Genomic Testing in Adult Adoptees.” Genetics in medicine : official journal of the American College of Medical Genetics 18 (9): 924-932. doi:10.1038/gim.2015.192. http://dx.doi.org/10.1038/gim.2015.192.1098-3600http://nrs.harvard.edu/urn-3:HUL.InstRepos:29407722Purpose American adult adoptees may possess limited amounts of information about their biological families and turn to direct-to-consumer personal genomic testing (PGT) for genealogical and medical information. We investigated the motivations and outcomes of adoptees undergoing PGT using data from the Impact of Personal Genomics (PGen) Study. Methods: The PGen Study surveyed new 23andMe and Pathway Genomics customers prior to and 6 months after receiving PGT results. Exploratory analyses compared adoptees’ and non-adoptees’ PGT attitudes, expectations, and experiences. We evaluated the association of adoption status with motivations for testing and post-disclosure actions using logistic regression models. Results: Of 1607 participants, 80 (5%) were adopted. As compared to non-adoptees, adoptees were more likely to cite limited family health history knowledge (OR = 10.1; 95% CI = 5.7–19.5) and the opportunity to learn genetic disease risks (OR = 2.7; 95% CI = 1.6–4.8) as strong motivations for PGT. Of 922 participants who completed 6-month follow-up, there was no significant association between adoption status and PGT-motivated healthcare utilization or health behavior change. Conclusion: PGT allows adoptees to gain otherwise inaccessible information about their genetic disease risks and ancestry, helping them to fill the void of an incomplete family health history.en-USAdult adopteeadoptiondirect-to-consumer genetic testingpersonal genomic testingfamily historyJournal Article2016-11-1810.1038/gim.2015.192