Vlassarev, Dimitar M.Golovchenko, Jene2016-08-232012Vlassarev, Dimitar M., and Jene A. Golovchenko. 2012. “Trapping DNA Near a Solid-State Nanopore.” Biophysical Journal 103 (2) (July): 352–356. doi:10.1016/j.bpj.2012.06.008.http://nrs.harvard.edu/urn-3:HUL.InstRepos:27877631We demonstrate that voltage biased solid-state nanopores can transiently localize DNA in an electrolyte solution. A double-stranded DNA (dsDNA) molecule is trapped when the electric field near the nanopore attracts and immobilizes a non-end segment of the molecule across the nanopore orifice without inducing a folded molecule translocation. In this demonstration of the phenomenon the ionic current through the nanopore decreases when the dsDNA molecule is trapped by the nanopore. By contrast, a translocating dsDNA molecule under the same conditions causes an ionic current increase. We also present finite element modeling results that predict this behavior for the conditions of the experiment.en-USJournal Article2016-08-2310.1016/j.bpj.2012.06.008