Colella, MatildeGerbino, AndreaHofer, AldebaranCurci, Silvana2016-11-182016Colella, Matilde, Andrea Gerbino, Aldebaran M. Hofer, and Silvana Curci. 2016. “Recent advances in understanding the extracellular calcium-sensing receptor.” F1000Research 5 (1): F1000 Faculty Rev-2535. doi:10.12688/f1000research.8963.1. http://dx.doi.org/10.12688/f1000research.8963.1.2046-1402http://nrs.harvard.edu/urn-3:HUL.InstRepos:29408169The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca 2+ and a surfeit of other endogenous ligands into multiple intracellular signals, but how is this achieved? This review will focus on some of the exciting concepts in CaR signaling and pharmacology that have emerged in the last few years.en-USArticlesCell SignalingCell Signaling & Trafficking StructuresDrug Discovery & DesignEndocrine & Metabolic PharmacologyMembranes & SortingMolecular Pharmacologyextracellular Ca2+ sensorCaRreceptor traffickingJournal Article2016-11-1810.12688/f1000research.8963.1