Verweij, NiekMateo Leach, IreneIsaacs, AaronArking, Dan E.Bis, Joshua C.Pers, Tune HVan Den Berg, Marten E.Lyytikäinen, Leo-PekkaBarnett, PhilWang, XinchenSoliman, Elsayed Z.Van Duijn, Cornelia M.Kähönen, MikaVan Veldhuisen, Dirk J.Kors, Jan A.Raitakari, Olli T.Silva, Claudia T.Lehtimäki, TerhoHillege, Hans L.Hirschhorn, JoelBoyer, Laurie A.Van Gilst, Wiek H.Alonso, AlvaroSotoodehnia, NonaEijgelsheim, MarkDe Boer, Rudolf A.De Bakker, Paul I. W.Franke, LudeVan Der Harst, Pim2016-11-182016Verweij, N., I. Mateo Leach, A. Isaacs, D. E. Arking, J. C. Bis, T. H. Pers, M. E. Van Den Berg, et al. 2016. “Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram.” Human Molecular Genetics 25 (10): 2093-2103. doi:10.1093/hmg/ddw058. http://dx.doi.org/10.1093/hmg/ddw058.0964-6906http://nrs.harvard.edu/urn-3:HUL.InstRepos:29408303The ST-segment and adjacent T-wave (ST-T wave) amplitudes of the electrocardiogram are quantitative characteristics of cardiac repolarization. Repolarization abnormalities have been linked to ventricular arrhythmias and sudden cardiac death. We performed the first genome-wide association meta-analysis of ST-T-wave amplitudes in up to 37 977 individuals identifying 71 robust genotype–phenotype associations clustered within 28 independent loci. Fifty-four genes were prioritized as candidates underlying the phenotypes, including genes with established roles in the cardiac repolarization phase (SCN5A/SCN10A, KCND3, KCNB1, NOS1AP and HEY2) and others with as yet undefined cardiac function. These associations may provide insights in the spatiotemporal contribution of genetic variation influencing cardiac repolarization and provide novel leads for future functional follow-up.en-USJournal Article2016-11-1810.1093/hmg/ddw058