Pomerantz, MarkAhmadiyeh, NasimJia, LiHerman, PaulaVerzi, MichaelDoddapaneni, HarshavardhanBeckwith, Christine A.Chan, Jennifer A.Hills, AdamDavis, MattYao, KeluoKehoe, Sarah M.Lenz, Heinz-JosefHaiman, Christopher A.Yan, ChunliHenderson, Brian E.Frenkel, BaruchBarretina, JordiBass, AdamTabernero, JosepBaselga, JoseRegan, MeredithManak, J. RobertShivdasani, RameshCoetzee, Gerhard A.Freedman, Matthew2022-07-222009-06-28Pomerantz, Mark, Nasim Ahmadiyeh, Li Jia, Paula Herman, Michael Verzi, Harshavardhan Doddapaneni, Christine A. Beckwith et al. "The 8q24 Cancer Risk Variant Rs6983267 Shows Long-Range Interaction With MYC in Colorectal Cancer." Nature Genetics 41, no. 8 (2009): 882-884. DOI: 10.1038/ng.4031061-40361546-1718https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372806An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that this region is a transcriptional enhancer, that the risk region physically interacts with the MYC proto-oncogene, and that the alleles of rs6983267 differentially bind transcription factor 7-like 2 (TCF7L2). These data provide strong support for a biological mechanism underlying this non-protein coding risk variant.en-USGeneticsJournal Article2022-07-2210.1038/ng.403