Federation, Alexander JBradner, James EMeissner, Alexander2017-07-202014Federation, Alexander J., James E. Bradner, and Alexander Meissner. 2014. “The Use of Small Molecules in Somatic-Cell Reprogramming.” Trends in Cell Biology 24 (3) (March): 179–187. doi:10.1016/j.tcb.2013.09.011.0962-8924http://nrs.harvard.edu/urn-3:HUL.InstRepos:33471097Pioneering work over the past years has highlighted the remarkable ability of manipulating cell states through exogenous, mostly transcription factor-induced reprogramming. The use of small molecules and reprogramming by transcription factors share a common history starting with the early AZA and MyoD experiments in fibroblast cells. Recent work shows that a combination of small molecules can replace all of the reprogramming factors and many previous studies have demonstrated their use in enhancing efficiencies or replacing individual factors. Here we provide a brief introduction to reprogramming followed by a detailed review of the major classes of small molecules that have been used to date and what future opportunities can be expected from these.en-USinduced pluripotent stem cellssmall moleculesreprogrammingchemical biologyepigeneticsJournal Article2015-08-17Federation AJ, Bradner JE, Meissner A10.1016/j.tcb.2013.09.011