Lai, Ka-Man VenusGong, GuochunAtanasio, AmandaRojas, JoséQuispe, JosephPosca, JulitaWhite, DerekHuang, MeiFedorova, DariaGrant, CraigMiloscio, LawrenceDroguett, GustavoPoueymirou, William T.Auerbach, WojtekYancopoulos, George D.Frendewey, DavidRinn, JohnValenzuela, David M.2015-06-022015Lai, K. V., G. Gong, A. Atanasio, J. Rojas, J. Quispe, J. Posca, D. White, et al. 2015. “Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs.” PLoS ONE 10 (4): e0125522. doi:10.1371/journal.pone.0125522. http://dx.doi.org/10.1371/journal.pone.0125522.1932-6203http://nrs.harvard.edu/urn-3:HUL.InstRepos:16120839In a survey of 20 knockout mouse lines designed to examine the biological functions of large intergenic non-coding RNAs (lincRNAs), we have found a variety of phenotypes, ranging from perinatal lethality to defects associated with premature aging and morphological and functional abnormalities in the lungs, skeleton, and muscle. Each mutant allele carried a lacZ reporter whose expression profile highlighted a wide spectrum of spatiotemporal and tissue-specific transcription patterns in embryos and adults that informed our phenotypic analyses and will serve as a guide for future investigations of these genes. Our study shows that lincRNAs are a new class of encoded molecules that, like proteins, serve essential and important functional roles in embryonic development, physiology, and homeostasis of a broad array of tissues and organs in mammals.en-USJournal Article2015-06-0210.1371/journal.pone.0125522