Jalbut, Marla M.Sohani, Aliyah R.Cin, Paola DalHasserjian, RobertMoran, Jenna A.Brunner, AndrewFathi, Amir2015-06-022015Jalbut, Marla M., Aliyah R. Sohani, Paola Dal Cin, Robert P. Hasserjian, Jenna A. Moran, Andrew M. Brunner, and Amir T. Fathi. 2015. “Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype.” Leukemia Research Reports 4 (1): 28-30. doi:10.1016/j.lrr.2015.04.001. http://dx.doi.org/10.1016/j.lrr.2015.04.001.2213-0489http://nrs.harvard.edu/urn-3:HUL.InstRepos:16120851Klinefelter syndrome (KS), a 47,XXY chromosomal abnormality, has been shown to be associated with a number of malignancies, but has not been linked to acute leukemias to date. We present a case of a 54-year-old male diagnosed with acute myeloid leukemia (AML) with monocytic differentiation, whose cytogenetic and subsequent FISH analyses revealed a constitutional 47,XXY karyotype. We also review and discuss relevant prior literature.en-USAcute myeloid leukemiaKlinefelter syndromeConstitutional chromosomal abnormalityJournal Article2015-06-0210.1016/j.lrr.2015.04.001