Wood, Andrew REsko, TõnuYang, JianVedantam, SailajaPers, Tune HGustafsson, StefanChu, Audrey Yu-leiEstrada, KarolLuan, Jian’anKutalik, ZoltánAmin, NajafBuchkovich, Martin LCroteau-Chonka, DamienDay, Felix RDuan, YananFall, ToveFehrmann, RudolfFerreira, TeresaJackson, Anne UKarjalainen, JuhaLo, Ken SinLocke, Adam EMägi, ReedikMihailov, EvelinPorcu, EleonoraRandall, Joshua CScherag, AndréVinkhuyzen, Anna AEWestra, Harm-JanWinkler, Thomas WWorkalemahu, TsegaselassieZhao, Jing HuaAbsher, DevinAlbrecht, EvaAnderson, DeniseBaron, JeffreyBeekman, MarianDemirkan, AyseEhret, Georg BFeenstra, BjarkeFeitosa, Mary FFischer, KristaFraser, Ross MGoel, AnujGong, JianJustice, Anne EKanoni, StavroulaKleber, Marcus EKristiansson, KatiLim, UnheeLotay, VaneetLui, Julian CMangino, MassimoLeach, Irene MateoMedina-Gomez, CarolinaNalls, Michael ANyholt, Dale RPalmer, Cameron DPasko, DorotaPechlivanis, SonaliProkopenko, IngaRied, Janina SRipke, StephanShungin, DmitryStancáková, AlenaStrawbridge, Rona JSung, Yun JuTanaka, ToshikoTeumer, AlexanderTrompet, Stellavan der Laan, Sander Wvan Setten, JessicaVan Vliet-Ostaptchouk, Jana VWang, ZhaomingYengo, LoïcZhang, WeihuaAfzal, UzmaÄrnlöv, JohanArscott, Gillian MBandinelli, StefaniaBarrett, AmyBellis, ClaireBennett, Amanda JBerne, ChristianBlüher, MatthiasBolton, Jennifer LBöttcher, YvonneBoyd, Heather ABruinenberg, MarcelBuckley, Brendan MBuyske, StevenCaspersen, Ida HChines, Peter SClarke, RobertClaudi-Boehm, SimoneCooper, MatthewDaw, E WarwickDe Jong, Pim ADeelen, JorisDelgado, GracielaDenny, Josh CDhonukshe-Rutten, RosalieDimitriou, MariaDoney, Alex SFDörr, MarcusEklund, NiinaEury, ElodieFolkersen, LasseGarcia, Melissa EGeller, FrankGiedraitis, VilmantasGo, Alan SGrallert, HaraldGrammer, Tanja BGräßler, JürgenGrönberg, Henrikde Groot, Lisette C.P.G.M.Groves, Christopher JHaessler, JeffreyHall, PerHaller, ToomasHallmans, GoranHannemann, AnkeHartman, Catharina AHassinen, MaijaHayward, CarolineHeard-Costa, Nancy LHelmer, QuintaHemani, 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Willem HPasterkamp, GerardPeters, AnnettePramstaller, Peter PPrice, Jackie FQi, LuRaitakari, Olli TRankinen, TuomoRao, DCRice, Treva KRitchie, MarylynRudan, IgorSalomaa, VeikkoSamani, Nilesh JSaramies, JoukoSarzynski, Mark ASchwarz, Peter EHSebert, SylvainSever, PeterShuldiner, Alan RSinisalo, JuhaSteinthorsdottir, ValgerdurStolk, Ronald PTardif, Jean-ClaudeTönjes, AnkeTremblay, AngeloTremoli, ElenaVirtamo, JarmoVohl, Marie-ClaudeAmouyel, PhilippeAsselbergs, Folkert WAssimes, Themistocles LBochud, MurielleBoehm, Bernhard OBoerwinkle, EricBottinger, Erwin PBouchard, ClaudeCauchi, StéphaneChambers, John CChanock, Stephen JCooper, Richard Sde Bakker, Paul IWDedoussis, GeorgeFerrucci, LuigiFranks, PaulFroguel, PhilippeGroop, Leif CHaiman, Christopher AHamsten, AndersHayes, M GeoffreyHui, JennieHunter, DavidHveem, KristianJukema, J WouterKaplan, Robert CKivimaki, MikaKuh, DianaLaakso, MarkkuLiu, YongmeiMartin, Nicholas GMärz, WinfriedMelbye, MadsMoebus, SusanneMunroe, Patricia BNjølstad, IngerOostra, Ben APalmer, Colin NAPedersen, Nancy LPerola, MarkusPérusse, LouisPeters, UlrikePowell, Joseph EPower, ChrisQuertermous, ThomasRauramaa, RainerReinmaa, EvaRidker, PaulRivadeneira, FernandoRotter, Jerome ISaaristo, Timo ESaleheen, DanishSchlessinger, DavidSlagboom, P ElineSnieder, HaroldSpector, Tim DStrauch, KonstantinStumvoll, MichaelTuomilehto, JaakkoUusitupa, Mattivan der Harst, PimVölzke, HenryWalker, MarkWareham, Nicholas JWatkins, HughWichmann, H-ErichWilson, James FZanen, PieterDeloukas, PanosHeid, Iris MLindgren, Cecilia MMohlke, Karen LSpeliotes, Elizabeth KThorsteinsdottir, UnnurBarroso, InêsFox, Caroline SNorth, Kari EStrachan, David PBeckmann, Jacques S.Berndt, Sonja IBoehnke, MichaelBorecki, Ingrid BMcCarthy, Mark IMetspalu, AndresStefansson, KariUitterlinden, André Gvan Duijn, Cornelia MFranke, LudeWiller, Cristen JPrice, AlkesLettre, GuillaumeLoos, Ruth JFWeedon, Michael NIngelsson, ErikO’Connell, Jeffrey RAbecasis, Goncalo RChasman, DanielGoddard, Michael EVisscher, Peter MHirschhorn, JoelFrayling, Timothy M2015-06-022014Wood, A. R., T. Esko, J. Yang, S. Vedantam, T. H. Pers, S. Gustafsson, A. Y. Chu, et al. 2014. “Defining the role of common variation in the genomic and biological architecture of adult human height.” Nature genetics 46 (11): 1173-1186. doi:10.1038/ng.3097. http://dx.doi.org/10.1038/ng.3097.1061-4036http://nrs.harvard.edu/urn-3:HUL.InstRepos:16120873Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explain one-fifth of heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ~2,000, ~3,700 and ~9,500 SNPs explained ~21%, ~24% and ~29% of phenotypic variance. Furthermore, all common variants together captured the majority (60%) of heritability. The 697 variants clustered in 423 loci enriched for genes, pathways, and tissue-types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/beta-catenin, and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.en-USJournal Article2015-06-0210.1038/ng.3097