Ke, YonggangOng, Luvena L.Sun, WeiSong, JieDong, MingdongShih, WilliamYin, Peng2015-06-022014Ke, Yonggang, Luvena L. Ong, Wei Sun, Jie Song, Mingdong Dong, William M. Shih, and Peng Yin. 2014. “DNA Brick Crystals with Prescribed Depth.” Nature chemistry 6 (11): 994-1002. doi:10.1038/nchem.2083. http://dx.doi.org/10.1038/nchem.2083.1755-4330http://nrs.harvard.edu/urn-3:HUL.InstRepos:16121056We describe a general framework for constructing two-dimensional crystals with prescribed depth and sophisticated three-dimensional features. These crystals may serve as scaffolds for the precise spatial arrangements of functional materials for diverse applications. The crystals are self-assembled from single-stranded DNA components called DNA bricks. We demonstrate the experimental construction of DNA brick crystals that can grow to micron-size in the lateral dimensions with precisely controlled depth up to 80 nanometers. They can be designed to display user-specified sophisticated three-dimensional nanoscale features, such as continuous or discontinuous cavities and channels, and to pack DNA helices at parallel and perpendicular angles relative to the plane of the crystals.en-USJournal Article2015-06-0210.1038/nchem.2083