Kazerounian, ShidehCiarlini, Pedro D.S.C.Yuan, DanielGhazvinian, RoxanneAlberich-Jorda, MeritxellJoshi, MugdhaZhang, HongBeggs, AlanGazda, Hanna2016-02-012016Kazerounian, Shideh, Pedro D.S.C. Ciarlini, Daniel Yuan, Roxanne Ghazvinian, Meritxell Alberich-Jorda, Mugdha Joshi, Hong Zhang, Alan H. Beggs, and Hanna T. Gazda. 2016. “Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice.” Journal of Cancer 7 (1): 32-36. doi:10.7150/jca.13292. http://dx.doi.org/10.7150/jca.13292.1837-9664http://nrs.harvard.edu/urn-3:HUL.InstRepos:24983888Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure syndrome associated with ribosomal protein (RP) gene mutations. Recent studies have also demonstrated an increased risk of cancer predisposition among DBA patients. In this study, we report the formation of soft tissue sarcoma in the Rpl5 and Rps24 heterozygous mice. Our observation suggests that even though one wild-type allele of the Rpl5 or Rps24 gene prevents anemia in these mice, it still predisposes them to cancer development.en-USRibosomal proteins RPL5 and RPS24Diamond-Blackfan anemiaSoft tissue sarcomaJournal Article2016-02-0110.7150/jca.13292